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    v1.0.31
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0102u-breastnext-genomic-sequence-analysis-17-gene-panel
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    CPT 0102U: BreastNext® 17-Gene Hereditary Breast Cancer Panel

    CPT code 0102U is a Proprietary Laboratory Analyses (PLA) code reported for the BreastNext® test from Ambry Genetics®, representing a genomic sequence analysis panel of 17 genes associated with hereditary breast cancer–related disorders; the service is a molecular diagnostic hereditary cancer panel (genomic sequencing analysis) typically performed by a clinical laboratory and billed for laboratory-based genetic testing, usually with specimen collection and processing at a clinical laboratory or reference lab site of service.

    For related coverage guidance, see recent payer policy updates: Minimal Residual Disease (MRD) Testing for Cancer, Biomarker Testing Mandate, Prenatal (Fetal) Diagnostic Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a woman with a personal or family history suggestive of hereditary breast cancer presenting to a genetics clinic or oncology practice. Common presentations include early-onset invasive breast cancer (diagnosed before age 50), bilateral breast cancer, a strong family history of breast and/or ovarian cancer, or a known pathogenic variant in a relative. The clinical workflow begins with a genetic counseling visit where personal and family history are reviewed and informed consent for testing is obtained. A clinician orders the BreastNext® test (0102U) specifying the indication. A blood or saliva specimen is collected in an outpatient clinic, ambulatory surgery center, or a hospital outpatient lab and sent to the proprietary laboratory (Ambry Genetics®). The laboratory performs targeted genomic sequencing and variant interpretation across the 17 genes included in the panel and issues a report identifying pathogenic, likely pathogenic, variants, variants of uncertain significance, and benign findings. Results are returned to the ordering clinician and reviewed with the patient in a follow-up visit or telehealth session to discuss implications for surveillance, risk-reduction strategies, and cascade testing for family members. Billing uses the PLA code 0102U with an appropriate ICD-10 code reflecting the clinical indication on the claim and may include a modifier when clinically applicable (for example, reporting the professional component or unusual circumstances).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0102UBreastNext®; genomic sequence analysis panel of 17 genes associated with hereditary breast cancer–related disorders (PLA)Primary billing code for the proprietary laboratory analysis performed by Ambry Genetics®.
    88381Consultation and interpretation, molecular pathology procedure (if used)May be reported by a pathologist or molecular genetics professional who provides a separate interpretive consultation beyond the standard report.
    81479Unlisted molecular pathology procedureOccasionally used by payers if PLA codes are not recognized or for additional unlisted molecular testing components not covered by the PLA.
    81025Urinalysis non-automated (not directly related)Data not available in the input.
    36415Collection of venous blood by venipunctureCommon ancillary service for specimen collection for genomic testing; billed by facility or phlebotomy service when separate from the lab charge.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207K00000X
    207L00000X
    207P00000X
    363L00000X
    171WH0202X
    156FX1900X
    2084P2900X

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Minimal Residual Disease (MRD) Testing for Cancerregence2027-01-01
    Biomarker Testing MandateBlue Cross Blue Shield - Rhode Island2027-01-01
    Prenatal (Fetal) Diagnostic TestingBlue Cross Blue Shield - Rhode Island2027-01-01
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Polygenic Risk ScoreBlue Cross Blue Shield - Rhode Island2026-12-01
    Gene Expression Profiling for Cutaneous MelanomaBlue Cross Blue Shield - Rhode Island2026-12-01
    Genetic Testing for Macular Degenerationregence2026-11-01
    Pharmacogenetic Panel Testing (for Ohio Only)Colorado Rocky Mountain Health Plans2026-11-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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