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    v1.0.30
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0096u-male-urine-high-risk-hpv-pcr-cobas
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    CPT 0096U: High-risk HPV PCR Test on Male Urine Specimen

    CPT code 0096U describes a Proprietary Laboratory Analyses (PLA) test: an automated PCR assay (Roche Cobas® performed by Molecular Testing Labs) for detection of 14 high–risk human papillomavirus (HPV) genotypes using a male urine specimen; service type is molecular diagnostic laboratory testing and typical site of service is clinical laboratory or outpatient specimen collection.

    For related coverage guidance, see recent payer policy updates: Prenatal (Fetal) Diagnostic Testing, Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency.

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old male presents to an outpatient urology or sexual health clinic requesting noninvasive screening for high‑risk human papillomavirus (HPV) after a partner has a recent abnormal cervical screening. A midstream urine specimen is collected in the clinic and sent to Molecular Testing Labs for analysis using the Roche Cobas® automated PCR platform. The test is a Proprietary Laboratory Analyses code reported as 0096U and identifies 14 high‑risk HPV genotypes. Typical workflow: order placed in the electronic health record, patient voids into a sterile container per collection instructions, specimen labeled and transported to the clinic laboratory or couriered to the reference lab, accessioning, automated PCR processing on the Roche Cobas® system, results routed back to the ordering clinician. Results are used for sexual health counseling, risk assessment, and possible referral for further evaluation if positive (for example, visual inspection or specialty referral). Typical site of service: outpatient clinic, ambulatory care center, or reference laboratory performing the test.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87491Infectious agent detection by nucleic acid (DNA or RNA); human papillomavirus (HPV), high‑risk types, direct probe technique, 1–5 types, qualitativeAlternative molecular HPV test sometimes used instead of the specific PLA 0096U when not using a proprietary assay; used in workflows when non‑proprietary codes apply.
    87623Infectious agent detection by nucleic acid (DNA or RNA); human papillomavirus (HPV), types 16 and 18 and high‑risk types, multiplex reverse transcription or amplification, each type, direct probe technique, includes typingAnother commonly billed HPV molecular assay that may be ordered for broader genotyping in male patients; may be performed when lab does not use the Roche Cobas® proprietary assay.
    99000Handling and/or conveyance of specimens for transfer from the office to a laboratoryAncillary code used for specimen handling and shipping when the clinic bills for specimen transport associated with sending urine to a reference lab.
    G0476Clinical Laboratory Improvement Amendments (CLIA) waived test (not otherwise classified)May apply in payer-specific reporting contexts for waived or point-of-care molecular tests; listed here as a related laboratory billing consideration.
    0001UProprietary Laboratory Analyses (example PLA)Other PLA codes may be billed for different proprietary HPV assays; listed to indicate that 0096U belongs to the PLA family of codes.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    103K00000X
    2080P0208X
    207Q00000X
    208D00000X
    207VG0400X
    103TH0100X
    364SF0001X
    273Y00000X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    A64Unspecified sexually transmitted disease
    B96.89Other specified bacterial agents as the cause of diseases classified elsewhere
    B97.7Papillomavirus as the cause of diseases classified elsewhere
    C53.9Malignant neoplasm of cervix uteri, unspecified
    D07.0Carcinoma in situ of endometrium
    D07.1Carcinoma in situ of vulva
    E66.9Obesity, unspecified
    F10.20Alcohol dependence, uncomplicated
    N87.9Dysplasia of cervix uteri, unspecified
    N99.89Other postprocedural complications and disorders of genitourinary system

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Prenatal (Fetal) Diagnostic TestingBlue Cross Blue Shield - Rhode Island2027-01-01
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Polygenic Risk ScoreBlue Cross Blue Shield - Rhode Island2026-12-01
    Gene Expression Profiling for Cutaneous MelanomaBlue Cross Blue Shield - Rhode Island2026-12-01
    Genetic Testing for Diagnosis and Management of Mental Health ConditionsBlue Cross Blue Shield - Rhode Island2026-11-01
    Molecular Testing in the Management of Pulmonary NodulesBlue Cross Blue Shield - Rhode Island2026-11-01
    Genetic Testing for Hereditary Cancer (for North Carolina Only)Colorado Rocky Mountain Health Plans2026-10-01
    Expanded Molecular Testing of Cancers to Select Targeted TherapiesBlue Cross Blue Shield - North Dakota2026-10-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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