Summary & Overview
CPT 0084U: BLOODchip®ID CORE XT™ RBC Antigen Phenotyping
CPT code 0084U designates the BLOODchip®ID CORE XT™ proprietary laboratory test from Grifols Diagnostic Solutions Inc., a molecular assay that identifies red blood cell (RBC) antigen phenotypes across 10 blood groups and predicts 37 erythrocyte antigen phenotypes. The code matters nationally because precise RBC antigen typing supports transfusion safety, donor-recipient compatibility, and can reduce alloimmunization and transfusion complications in complex or sensitized patients. Laboratories, transfusion services, and blood centers use this specific PLA-coded test when standard serologic typing is insufficient or when molecular resolution is required.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the test’s clinical role and coding designation, payer coverage context, and the types of benchmarks and policy elements typically addressed for PLA molecular assays. The publication summarizes payment and coverage variation landscape, common billing modifiers and coding considerations, clinical indications that drive use of molecular RBC phenotyping, and where national policy updates or coding clarifications may affect billing practices. Data not available in the input is noted where applicable.
Billing Code Overview
CPT code 0084U is a Proprietary Laboratory Analyses (PLA) code for the BLOODchip®ID CORE XT™ test from Grifols Diagnostic Solutions Inc. The test is a molecular-based assay that identifies blood donor and recipient red blood cell (RBC) antigen phenotypes to assist with blood compatibility determination. It detects markers across 10 blood groups and predicts 37 human erythrocyte antigen phenotypes.
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Service type: Molecular-based laboratory assay for RBC antigen phenotyping
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Typical site of service: Clinical laboratory or specialized blood bank laboratory
Clinical & Coding Specifications
Clinical Context
A 42-year-old woman with a history of multiple prior transfusions presents for elective surgery and requires pre-transfusion red blood cell compatibility testing. The transfusion medicine service orders a molecular antigen typing assay to determine donor and recipient erythrocyte antigen profiles when serologic typing is inconclusive or when extended antigen matching is needed (for example, in patients with alloantibodies, sickle cell disease, or chronically transfused patients). A phlebotomy specimen is collected and sent to the reference laboratory performing the BLOODchip®ID CORE XT™ assay. The laboratory performs DNA-based molecular testing to identify 37 human erythrocyte antigen phenotypes across 10 blood group systems and reports results to the transfusion service. Results guide selection of antigen-matched blood units and compatibility decisions, and are documented in the patient’s transfusion record and laboratory information system. Typical site of service: hospital laboratory or independent clinical diagnostic laboratory; service type: proprietary molecular laboratory assay (Proprietary Laboratory Analyses, PLA).
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier reported | Use when no additional modifier applies to the claim |
11 | Office or other outpatient service | Use when the specimen originates from an outpatient/clinic encounter |
26 | Professional component | Use when reporting only the professional interpretation or consultation portion if separated |
TC | Technical component | Use when reporting only the technical component (laboratory processing) |
59 | Distinct procedural service | Use when this test is distinct and separately reportable from another service on the same day |
62 | Two surgeons | Rare for this lab code; use only if two qualified professionals share responsibility for interpretation |
80 | Assistant surgeon | Not typical for lab testing; included for completeness if applicable in combined services |
82 | Assistant surgeon (when qualified resident not available) | As above; uncommon for laboratory PLA codes |
QX | Ordering/servicing physician CRNA certification modifier | Use if applicable to billing rules requiring clinician qualifications (context-specific) |
SH | Outpatient hospital facility | Use when testing is billed under outpatient hospital facility billing arrangements |
| Taxonomy Code | Specialty | Notes |
|---|---|---|
207L00000X | Pathology | Laboratory oversight, molecular diagnostics interpretation |
2080P0005X | Clinical Laboratory | Clinical laboratory directors and high-complexity testing oversight |
207Q00000X | Hematology | Transfusion medicine and blood bank specialty involvement |
207K00000X | Medical Genetics | Molecular testing and genotype interpretation when consulted |
207NG0200X | Pediatrics (Hematology) | Pediatric hematology involvement for chronically transfused children |
Related Diagnoses
| ICD-10 Code | Description | Clinical Relevance |
|---|---|---|
D57.0 | Hb-SS disease with crisis | Chronic transfusion and alloimmunization risk; extended antigen typing guides compatible transfusions |
D57.1 | Sickle-cell disease without crisis | Patients frequently require antigen-matched blood for transfusions |
D61.09 | Other autoimmune hemolytic anemias | Hemolytic disorders where alloantibody evaluation and antigen matching may be needed |
D50.9 | Iron deficiency anemia, unspecified | Preoperative or transfusion evaluation when serologic typing may be supplemented by molecular testing in complex cases |
Z51.0 | Encounter for antineoplastic chemotherapy and immunotherapy | Patients receiving therapies that may require transfusion support and extended antigen matching |
T86.1 | Complications of transplanted organ and tissue, not elsewhere classified | Post-transplant patients may have complex transfusion needs requiring molecular typing |
O99.82 | Blood disorders complicating pregnancy, not elsewhere classified | Pregnant patients with alloantibodies or hemoglobinopathies may need antigen typing for transfusion planning |
Related CPT Codes
| CPT Code | Description | Relationship to This Procedure |
|---|---|---|
P9619 | Specimen handling and shipping (example PLA-related supply code) | May be reported by some laboratories for special handling/shipping associated with proprietary assays when allowed by payer policy |
36415 | Collection of venous blood by venipuncture | Blood sample collection performed prior to molecular antigen testing |
86141 | Blood typing; ABO | Routine serologic ABO typing often performed before or alongside molecular antigen assays |
86900 | Compatibility test, blood; crossmatch, serological | Serologic crossmatch before transfusion; molecular typing can supplement or replace some serologic workups |
88271 | Molecular pathology procedure level 1 | Related molecular testing category; labs may report molecular pathology codes when PLA reporting rules permit |