CPT 0079U: Urine Specimen Authentication by DNA Comparison

CPT code 0079U is a Proprietary Laboratory Analyses (PLA) test code describing ToxLok™ by InSource Diagnostics, a laboratory service that verifies a urine specimen is from the intended person by comparing DNA from a concurrently collected buccal (cheek) swab and urine specimen; service type: specimen authentication / identity verification by DNA comparison, typical site of service: clinical laboratory or contracted collection site.

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CPT 0079U: Urine Specimen Authentication by DNA Comparison

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Get alerted when payer policies referencing 0079U are released or updated.

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Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient scenario involves a patient presenting for urine drug testing, forensic collection, or specimen validity testing where chain-of-custody and specimen identity must be confirmed. At intake, a trained collector obtains a buccal (cheek) swab and a contemporaneous urine specimen from the same patient. Both specimens are labeled, documented, and sent to the laboratory. ToxLok™ (0079U) is performed by the manufacturer or designated lab to compare DNA from the buccal swab and extracted DNA from the urine specimen to confirm the urine originates from the intended individual. Results are reported as a match, non-match, or inconclusive, and are used to validate test results for clinical care, legal proceedings, workplace testing, or medication monitoring. Typical sites of service include outpatient clinics, addiction medicine programs, occupational health facilities, forensic collection centers, and commercial laboratories handling mailed or couriered specimens.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0080U`	Genomic test for specimen identity verification (example PLA companion code)	May be performed alongside `0079U` when additional proprietary specimen identity assays or alternative vendor tests are used in the same workflow.
`G0480`	Drug test, definitive, multiple drug classes, each procedure	Frequently ordered in the same episode of care; `0079U` confirms specimen identity when definitive drug testing is reported.
`80305`	Drug screen, presumptive, any number of drug classes by instrumented chemistry analyzers	Often preceded by presumptive screening; if confirmation testing is discrepant or chain-of-custody questioned, `0079U` may be ordered.
`87635`	Infectious agent detection by nucleic acid (example NAAT)	Not directly related clinically but represents lab-based nucleic acid testing workflows; included as an analogous lab molecular procedure performed in the same laboratory setting.
`89049`	Urinalysis, by automated instrument with microscopy	May be ordered in the same visit to assess urine characteristics when specimen validity or contamination is a concern; `0079U` provides identity verification complementary to urinalysis.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
55	Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…	- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207VC0200X	Critical Care Medicine (Obstetrics & Gynecology) Physician	An obstetrician/gynecologist, who specializes in critical care medicine diagnoses, treats and supports female patients with multiple organ dysfunction…
320700000X	Physical Disabilities Residential Treatment Facility	A residential facility that provides habilitation services and other care and treatment to adults or children diagnosed with physical disabilities and…
246QL0900X	Laboratory Management Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
2083T0002X	Medical Toxicology (Preventive Medicine) Physician	Medical toxicologists are physicians who specialize in the prevention, evaluation, treatment and monitoring of injury and illness from exposures to dr…
310500000X	Mental Illness Intermediate Care Facility	A nursing facility that provides an intermediate level of nursing care to individuals whose functional abilities are significantly compromise by menta…

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0080U`	Genomic test for specimen identity verification (example PLA companion code)	May be performed alongside `0079U` when additional proprietary specimen identity assays or alternative vendor tests are used in the same workflow.
`G0480`	Drug test, definitive, multiple drug classes, each procedure	Frequently ordered in the same episode of care; `0079U` confirms specimen identity when definitive drug testing is reported.
`80305`	Drug screen, presumptive, any number of drug classes by instrumented chemistry analyzers	Often preceded by presumptive screening; if confirmation testing is discrepant or chain-of-custody questioned, `0079U` may be ordered.
`87635`	Infectious agent detection by nucleic acid (example NAAT)	Not directly related clinically but represents lab-based nucleic acid testing workflows; included as an analogous lab molecular procedure performed in the same laboratory setting.
`89049`	Urinalysis, by automated instrument with microscopy	May be ordered in the same visit to assess urine characteristics when specimen validity or contamination is a concern; `0079U` provides identity verification complementary to urinalysis.

Related Modifiers

5 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
55	Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…	- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207VC0200X	Critical Care Medicine (Obstetrics & Gynecology) Physician	An obstetrician/gynecologist, who specializes in critical care medicine diagnoses, treats and supports female patients with multiple organ dysfunction…
320700000X	Physical Disabilities Residential Treatment Facility	A residential facility that provides habilitation services and other care and treatment to adults or children diagnosed with physical disabilities and…
246QL0900X	Laboratory Management Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
2083T0002X	Medical Toxicology (Preventive Medicine) Physician	Medical toxicologists are physicians who specialize in the prevention, evaluation, treatment and monitoring of injury and illness from exposures to dr…
310500000X	Mental Illness Intermediate Care Facility	A nursing facility that provides an intermediate level of nursing care to individuals whose functional abilities are significantly compromise by menta…

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0079U: Urine Specimen Authentication by DNA Comparison

Sign up for cpt 0079U policy alerts

OpenPayer

CPT 0079U: Urine Specimen Authentication by DNA Comparison

Sign up for cpt 0079U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 0079U: Urine Specimen Authentication by DNA Comparison

Sign up for cpt 0079U policy alerts

CPT 0079U: Urine Specimen Authentication by DNA Comparison

Sign up for cpt 0079U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0079U (ToxLok™) represent?

In what clinical settings or situations is 0079U commonly used?

Which billing modifiers are relevant for coding and billing 0079U?

What other CPT codes or tests are commonly associated with 0079U in an episode of care?

Which payers were reviewed and where should I look for coverage details for 0079U?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0079U (ToxLok™) represent?

In what clinical settings or situations is 0079U commonly used?

Which billing modifiers are relevant for coding and billing 0079U?

What other CPT codes or tests are commonly associated with 0079U in an episode of care?

Which payers were reviewed and where should I look for coverage details for 0079U?

References