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    v1.0.31
    OpenPayerBilling CodesProprietary Laboratory AnalysesCPT cpt-0063u-npdx-asd-adm-panel-1-amine-algorithmic-test
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    CPT 0063U: NPDX ASD ADM Panel I Metabolic Amine Analysis

    CPT code 0063U is a Proprietary Laboratory Analyses (PLA) code describing the NPDX ASD ADM Panel I from Stemina Biomarker Discovery, Inc., a laboratory-developed test that measures 32 amines and applies an algorithmic analysis to identify metabolic patterns consistent with autism spectrum disorder; service type: laboratory diagnostic assay with algorithmic interpretation; typical site of service: independent or hospital-based clinical laboratory.

    For related coverage guidance, see recent payer policy updates: Minimal Residual Disease (MRD) Testing for Cancer, Biomarker Testing Mandate, Prenatal (Fetal) Diagnostic Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric patient aged 18–48 months presents to a developmental pediatrics clinic for evaluation of delayed social communication, repetitive behaviors, and language regression. The clinician documents concern for autism spectrum disorder (ASD) after standardized screening (for example, M-CHAT) and developmental testing. As part of the diagnostic workup, the clinician orders the proprietary laboratory test 0063U (NPDX ASD ADM Panel I from Stemina Biomarker Discovery, Inc.) to assess a metabolic amine profile and algorithmic pattern consistent with ASD. Blood or plasma is collected in the outpatient clinic or affiliated phlebotomy lab; the specimen is sent to the performing laboratory under chain-of-custody and required transport conditions. The laboratory performs quantitative analysis of 32 amines and runs the manufacturer’s proprietary algorithm to generate a report indicating whether the metabolic pattern is consistent with ASD. Results are returned to the ordering clinician, who integrates the laboratory findings with clinical history, behavioral assessments, and developmental testing to inform diagnosis and care planning. Typical sites of service include outpatient physician offices, specialty developmental pediatrics clinics, hospital outpatient laboratories, and the performing reference laboratory. Technical billing for the test is submitted using PLA code 0063U with appropriate specimen and facility modifiers as needed; professional interpretation may be billed if the reporting laboratory or ordering clinician meets payer rules for reporting the professional component.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81002Urinalysis, non-automated, without microscopyPre-analytic screening or concurrent metabolic screening sometimes ordered in neurodevelopmental evaluations.
    80053Comprehensive metabolic panel (CMP)Routine metabolic screening that may be ordered alongside specialized biomarker panels to assess systemic contributors.
    81479Unlisted molecular pathology procedureUsed when no specific molecular/proprietary code exists for custom or novel analyses; historically used prior to availability of PLA codes like 0063U.
    82043Vitamin B12; measurementCommon adjunctive laboratory test during developmental or metabolic evaluations.
    83036Hemoglobin; glycosylated (A1C)Occasionally part of broader metabolic assessment in multidisciplinary evaluations.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207Q00000X
    1835G0000X
    2279C0205X
    1835P1300X
    364SN0800X
    1710I1003X
    341800000X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    F41.9Anxiety disorder, unspecified
    F71Moderate intellectual disabilities
    F72Severe intellectual disabilities
    F73Profound intellectual disabilities
    F79Unspecified intellectual disabilities
    F80.0Phonological disorder
    F80.1Expressive language disorder
    F80.2Mixed receptive-expressive language disorder
    F80.9Developmental disorder of speech and language, unspecified
    F84.0Autistic disorder

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Minimal Residual Disease (MRD) Testing for Cancerregence2027-01-01
    Biomarker Testing MandateBlue Cross Blue Shield - Rhode Island2027-01-01
    Prenatal (Fetal) Diagnostic TestingBlue Cross Blue Shield - Rhode Island2027-01-01
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Polygenic Risk ScoreBlue Cross Blue Shield - Rhode Island2026-12-01
    Gene Expression Profiling for Cutaneous MelanomaBlue Cross Blue Shield - Rhode Island2026-12-01
    Genetic Testing for Macular Degenerationregence2026-11-01
    Pharmacogenetic Panel Testing (for Ohio Only)Colorado Rocky Mountain Health Plans2026-11-01

    Related Codes

    CPT-0001U-PRECISETYPE-HEA-MULTIPLEX-RBC-ANTIGEN-GENOTYPING

    CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

    CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

    CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

    CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

    CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

    CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

    CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

    CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

    CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

    CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

    CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

    CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

    CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

    CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

    CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

    CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

    CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

    CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

    CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

    Showing 1–10 of 536

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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