Summary & Overview

CPT 0061U: Transcutaneous Multispectral Tissue Oxygenation Imaging

CPT code 0061U identifies a Proprietary Laboratory Analyses (PLA) test for transcutaneous multispectral measurement of five biomarkers of tissue oxygenation and hemoglobin using the Ox–Imager CS® spatial frequency domain imaging (SFDI) system. The code captures a noninvasive imaging-based diagnostic that assesses superficial tissue oxygenation, a key determinant of tissue health and wound healing, and thus has clinical importance in wound care, vascular assessment, and perioperative risk evaluation. Nationally, this PLA code represents an emerging, manufacturer-specific diagnostic technology with implications for clinical decision-making and coverage policies.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical context for the test, payer coverage considerations, and common billing elements such as applicable modifiers. The publication summarizes benchmarks where available, highlights relevant policy issues for a proprietary laboratory test, and provides operational details for coding and site-of-service expectations. Data not available in the input is noted where payer-specific coverage determinations, taxonomies, ICD-10 mappings, and related codes are not provided.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicare0061UCPTProprietary Laboratory Analysestissue oxygenationspatial frequency domain imagingOx-Imager CSdiagnostic imagingwound carenoninvasive testing

Billing Code Overview

CPT code 0061U is a Proprietary Laboratory Analyses (PLA) code for the transcutaneous multispectral measurement of five biomarkers of tissue oxygenation and hemoglobin using Ox–Imager CS®, Modulated Imaging’s spatial frequency domain imaging (SFDI) and multispectral analysis system. The procedure provides a noninvasive, surface-level assessment of tissue oxygenation to help identify superficial circulatory compromise and inform clinical evaluation of tissue health and healing.

Service type: Diagnostic laboratory imaging test (noninvasive multispectral tissue oxygenation measurement)

Typical site of service: Outpatient clinics, wound care centers, dermatology practices, vascular clinics, and other ambulatory care settings where noninvasive tissue oxygenation assessment is performed

Clinical & Coding Specifications

Clinical Context

A 68-year-old patient with peripheral arterial disease and a history of non-healing plantar foot ulcer presents to a vascular clinic for assessment of tissue perfusion to guide wound management. The vascular specialist orders a transcutaneous multispectral measurement using the Ox–Imager CS® SFDI multispectral analysis system to quantify superficial tissue oxygenation and hemoglobin content across the wound bed and periwound tissues. The test is performed in an outpatient vascular laboratory or wound care center with the patient in a supine or seated position; the technician calibrates the device, acquires multispectral images of the affected foot, and the system derives five biomarkers of tissue oxygenation and hemoglobin. Results are reviewed by the vascular specialist during the same visit to assess risk of ischemia, stratify need for revascularization or advanced wound therapies, and document baseline perfusion for serial monitoring.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	When only the physician interpretation/report is billed separate from the technical component
`TC`	Technical component	When only the device/equipment and technician services are billed

Taxonomy Code	Specialty	Notes
207RG0100X	Vascular Surgery	Vascular surgeons order and interpret tissue perfusion imaging for ischemia and wound care
207RH0000X	Thoracic and Cardiac Surgery	Surgeons involved in complex limb salvage decisions or revascularization planning
207L00000X	Wound Care Specialist	Clinicians in dedicated wound centers who use perfusion imaging to guide therapy
207Q00000X	Interventional Radiology	Interventional radiologists who perform revascularization procedures and use perfusion data for planning
207RC0000X	General Surgery	General surgeons involved in limb salvage and wound management

ICD-10 Code	Description	Clinical Relevance
`I70.219`	Atherosclerosis of native arteries of the extremities, unspecified extremity, with intermittent claudication	Macrovascular disease causing reduced tissue perfusion assessed by multispectral imaging
`I70.229`	Atherosclerosis of native arteries of the extremities, unspecified extremity, with rest pain	Severe ischemia where tissue oxygenation mapping guides urgency of intervention
`I70.239`	Atherosclerosis of native arteries of the extremities, unspecified extremity, with ulceration	Directly relevant for mapping perfusion at ulcer sites to guide wound care and revascularization
`I83.10`	Varicose veins of unspecified lower extremity with ulcer	Venous disease that may affect tissue oxygenation and wound healing patterns
`L97.909`	Non-pressure chronic ulcer of unspecified part of lower leg, unspecified severity	Common wound diagnosis where superficial oxygenation measurement informs treatment
`E11.621`	Type 2 diabetes mellitus with foot ulcer	Diabetes-related microvascular disease commonly evaluated with tissue oxygenation imaging
`T81.89XA`	Other complications of procedures, initial encounter	Used when documenting complications that may prompt repeat perfusion assessment
`R94.31`	Abnormal results of transcutaneous oxygen tension (if documented) — note: placeholder for abnormal perfusion findings reporting	Reflects abnormal perfusion findings that correlate with multispectral imaging biomarkers

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0061U`	Transcutaneous multispectral measurement of five biomarkers of tissue oxygenation and hemoglobin using Ox–Imager CS®, Modulated Imaging SFDI and multispectral analysis system	Primary PLA code describing this specific imaging perfusion test
`93922`	Duplex scan of arterial inflow and venous outflow of extremity, complete bilateral study	Frequently performed alongside to evaluate macrovascular arterial flow contributing to tissue oxygenation deficits
`93924`	Duplex scan of arterial inflow, unilateral or limited study	Used as a targeted vascular study when perfusion imaging suggests localized arterial compromise
`29581`	Application of multi-layer compression bandage for venous ulcer (example) — (Note: procedure code example for wound care interventions)	Often performed subsequent to perfusion assessment when venous insufficiency contributes to poor wound healing
`93976`	Noninvasive physiologic arterial studies of upper or lower extremity, single level, using plethysmography or segmental pressure	Provides complementary physiologic data on limb perfusion to correlate with superficial tissue oxygenation

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