CPT 0038U: Sensieva Droplet 25‑OH Vitamin D2/D3 LC–MS/MS Assay

CPT code 0038U is a Proprietary Laboratory Analyses (PLA) code for the Sensieva Droplet™ 25 OH vitamin D2/D3 microvolume LC/MS assay by InSource Diagnostics. It designates a manufacturer-specific quantitative laboratory test that measures 25-hydroxyvitamin D2 and D3 from a very small serum sample using liquid chromatography-tandem mass spectrometry. PLA codes like 0038U matter nationally because they uniquely identify proprietary tests, support claims processing and tracking of novel diagnostics, and inform coverage decisions and pricing discussions.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of clinical context for vitamin D testing, the technical method (LC–MS/MS) and its implications for analytic specificity, and the role of microvolume assays in settings with limited specimen. The publication summarizes expected service settings (clinical and reference laboratories), common modifiers that may appear on claims, and available payer coverage patterns where present. It also highlights benchmarking and policy considerations relevant to PLA-coded tests, including implications for coding consistency, claim adjudication, and national reporting.

Data not available in the input for associated taxonomies, ICD-10 diagnoses, related codes, and service line is noted where applicable.

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Billing Code Overview

CPT code 0038U is a Proprietary Laboratory Analyses (PLA) code that describes a single, manufacturer-specific laboratory test. The code identifies the Sensieva Droplet™ 25 OH vitamin D2/D3 microvolume LC/MS assay from InSource Diagnostics, a quantitative serum test for vitamin D (25-hydroxyvitamin D2 and D3) performed using liquid chromatography with tandem mass spectrometry (LC–MS/MS).

Service Type: Laboratory — quantitative LC–MS/MS assay for 25‑hydroxyvitamin D2/D3

Typical Site of Service: Clinical laboratory or reference laboratory using microvolume serum samples

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CPT 0038U: Sensieva Droplet 25‑OH Vitamin D2/D3 LC–MS/MS Assay

Data not available in the input for associated taxonomies, ICD-10 diagnoses, related codes, and service line is noted where applicable.

Customize your policy alerts

Sign up for cpt 0038U policy alerts

Get alerted when payer policies referencing 0038U are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Billing Code Overview

Service Type: Laboratory — quantitative LC–MS/MS assay for 25‑hydroxyvitamin D2/D3

Typical Site of Service: Clinical laboratory or reference laboratory using microvolume serum samples

Clinical & Coding Specifications

Clinical Context

A typical patient for the 0038U Sensieva Droplet™ 25 OH vitamin D2/D3 microvolume LC/MS assay is an outpatient or inpatient whose provider needs an accurate quantitative measurement of serum 25-hydroxyvitamin D2 and D3 from a very small blood volume. Common scenarios include: monitoring vitamin D status in infants and children with limited blood volume, tracking vitamin D therapy in patients with malabsorption or gastric bypass, evaluating hypocalcemia or metabolic bone disease, or confirming insufficiency/deficiency when immunoassay results are equivocal. The clinical workflow: a clinician orders 0038U on the laboratory requisition, a phlebotomist collects a microvolume serum sample (often from a capillary or small-volume venipuncture), the specimen is sent to the laboratory performing the proprietary LC–MS/MS assay, results are reported to the ordering provider, and the provider uses quantitative D2 and D3 results for diagnosis, monitoring therapy, or treatment planning. Typical sites of service include hospital outpatient laboratories, independent reference laboratories, specialty clinical laboratories, and neonatal or pediatric inpatient units where microvolume sampling is required.

Related Diagnoses

Frequently associated clinical diagnoses for ordering quantitative 25-hydroxyvitamin D2/D3 testing.

ICD-10 Code	Description	Clinical Relevance
`E55.9`	Vitamin D deficiency, unspecified	Primary indication for measuring serum 25-hydroxyvitamin D to confirm deficiency.
`E83.51`	Hypocalcemia	Vitamin D status is evaluated when hypocalcemia is present because deficiency can cause low calcium.
`M81.0`	Age-related osteoporosis without current pathological fracture	Vitamin D testing is part of metabolic evaluation in osteoporosis management.
`K90.0`	Celiac disease	Malabsorption disorders like celiac disease can cause vitamin D deficiency; monitoring is indicated.
`Z13.820`	Encounter for screening for osteoporosis	Vitamin D measurement may be ordered during osteoporosis screening or risk assessment.

Related CPT Codes

Common CPT codes performed alongside or in the workflow with 0038U.

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Used to collect the serum specimen for the vitamin D assay when venous microvolume collection is required.
`99495`	Data not available in the input.	Data not available in the input.
`80048`	Basic metabolic panel	Performed concurrently in patients being evaluated for metabolic or electrolyte abnormalities alongside vitamin D testing.
`82043`	Assay of 25-hydroxyvitamin D; immunoassay	Alternative method; may be ordered when LC–MS/MS is not available or as a comparative assay.
`83520`	Assay of 25-hydroxyvitamin D; mass spectrometry	Related technical methodology; labs may bill a mass spectrometry vitamin D assay when not using the PLA `0038U` specific test.

Related Modifiers

10 rows

Modifier	Description	When to Use
26	Professional component	Use when billing only the professional component (interpretation/oversight) separate from the technical laboratory processing, if applicable and permitted.
59	Data not available in the input.	Data not available in the input.
52	Reduced services	Use when the test is performed but services are partially reduced (for example, insufficient volume leads to partial panel reporting) and payer accepts modifier `52` for laboratory tests.
53	Discontinued procedure	Use when specimen collection or testing was started but discontinued for documented clinical reasons before completion.
76	Data not available in the input.	Data not available in the input.
78	Unplanned return to the operating/procedure room by the same physician following initial procedure for a related procedure during the postoperative period	Generally not applicable to this laboratory test; included in raw list but not typically used.
80	Data not available in the input.	Data not available in the input.
22	Increased procedural services	Use when the laboratory documents that the assay required substantially greater resources (rare for standardized PLA test; requires documentation and payer approval).
23	Unusual anesthesia	Not applicable for `0038U`; included in raw list but not typically used.
62	Two surgeons	Not applicable for this lab procedure.

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Pathology & Laboratory Medicine	Clinical pathologists oversee laboratory testing and result validation.
207K00000X	Clinical Laboratory	Clinical laboratory directors and supervisors manage testing operations and QA for LC–MS/MS assays.
208000000X	Pediatrics	Pediatricians commonly order microvolume vitamin D tests for infants and children.
363L00000X	Phlebotomy	Phlebotomists skilled in microvolume collection perform sample acquisition.
103TC1900X	Counseling Psychologist	A psychologist who specializes in general practice and health service. It focuses on how people function both personally and in their relationships at…
207T00000X	Neurological Surgery Physician	A neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
341600000X	Ambulance	An emergency vehicle used for transporting patients to a health care facility after injury or illness. Types of ambulances used in the United States i…
2084N0400X	Neurology Physician	A Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Frequently associated clinical diagnoses for ordering quantitative 25-hydroxyvitamin D2/D3 testing.

ICD-10 Code	Description	Clinical Relevance
`E55.9`	Vitamin D deficiency, unspecified	Primary indication for measuring serum 25-hydroxyvitamin D to confirm deficiency.
`E83.51`	Hypocalcemia	Vitamin D status is evaluated when hypocalcemia is present because deficiency can cause low calcium.
`M81.0`	Age-related osteoporosis without current pathological fracture	Vitamin D testing is part of metabolic evaluation in osteoporosis management.
`K90.0`	Celiac disease	Malabsorption disorders like celiac disease can cause vitamin D deficiency; monitoring is indicated.
`Z13.820`	Encounter for screening for osteoporosis	Vitamin D measurement may be ordered during osteoporosis screening or risk assessment.

Related CPT Codes

Common CPT codes performed alongside or in the workflow with 0038U.

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Used to collect the serum specimen for the vitamin D assay when venous microvolume collection is required.
`99495`	Data not available in the input.	Data not available in the input.
`80048`	Basic metabolic panel	Performed concurrently in patients being evaluated for metabolic or electrolyte abnormalities alongside vitamin D testing.
`82043`	Assay of 25-hydroxyvitamin D; immunoassay	Alternative method; may be ordered when LC–MS/MS is not available or as a comparative assay.
`83520`	Assay of 25-hydroxyvitamin D; mass spectrometry	Related technical methodology; labs may bill a mass spectrometry vitamin D assay when not using the PLA `0038U` specific test.

Related Modifiers

10 rows

Modifier	Description	When to Use
26	Professional component	Use when billing only the professional component (interpretation/oversight) separate from the technical laboratory processing, if applicable and permitted.
59	Data not available in the input.	Data not available in the input.
52	Reduced services	Use when the test is performed but services are partially reduced (for example, insufficient volume leads to partial panel reporting) and payer accepts modifier `52` for laboratory tests.
53	Discontinued procedure	Use when specimen collection or testing was started but discontinued for documented clinical reasons before completion.
76	Data not available in the input.	Data not available in the input.
78	Unplanned return to the operating/procedure room by the same physician following initial procedure for a related procedure during the postoperative period	Generally not applicable to this laboratory test; included in raw list but not typically used.
80	Data not available in the input.	Data not available in the input.
22	Increased procedural services	Use when the laboratory documents that the assay required substantially greater resources (rare for standardized PLA test; requires documentation and payer approval).
23	Unusual anesthesia	Not applicable for `0038U`; included in raw list but not typically used.
62	Two surgeons	Not applicable for this lab procedure.

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Pathology & Laboratory Medicine	Clinical pathologists oversee laboratory testing and result validation.
207K00000X	Clinical Laboratory	Clinical laboratory directors and supervisors manage testing operations and QA for LC–MS/MS assays.
208000000X	Pediatrics	Pediatricians commonly order microvolume vitamin D tests for infants and children.
363L00000X	Phlebotomy	Phlebotomists skilled in microvolume collection perform sample acquisition.
103TC1900X	Counseling Psychologist	A psychologist who specializes in general practice and health service. It focuses on how people function both personally and in their relationships at…
207T00000X	Neurological Surgery Physician	A neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
341600000X	Ambulance	An emergency vehicle used for transporting patients to a health care facility after injury or illness. Types of ambulances used in the United States i…
2084N0400X	Neurology Physician	A Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…

CPT 0001U: PreciseType HEA Multiplex Erythrocyte Antigen Assay

CPT-0002U-POLYPDX-URINE-METABOLOMIC-ASSAY-ADENOMATOUS-POLYP-RISK

CPT 0002U: Urine Metabolomic Polyp Risk Assay (PolypDX™)

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa™ (OVA1 Next Generation) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) Urine Gene Expression Risk Test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen with DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Panel, Gene Sequence Analysis

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Cordant CORE™ Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcript Testing

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0038U: Sensieva Droplet 25‑OH Vitamin D2/D3 LC–MS/MS Assay

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Billing Code Overview

OpenPayer

CPT 0038U: Sensieva Droplet 25‑OH Vitamin D2/D3 LC–MS/MS Assay

Sign up for cpt 0038U policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 0038U: Sensieva Droplet 25‑OH Vitamin D2/D3 LC–MS/MS Assay

Sign up for cpt 0038U policy alerts

Billing Code Overview

CPT 0038U: Sensieva Droplet 25‑OH Vitamin D2/D3 LC–MS/MS Assay

Sign up for cpt 0038U policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT 0038U represent?

In what clinical situations and sites of service is 0038U commonly used?

Which claim modifiers are most relevant when billing 0038U?

What other CPT codes are commonly performed with or related to 0038U?

Which payers are included and does the page provide coverage or reimbursement rates for 0038U?

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT 0038U represent?

In what clinical situations and sites of service is 0038U commonly used?

Which claim modifiers are most relevant when billing 0038U?

What other CPT codes are commonly performed with or related to 0038U?

Which payers are included and does the page provide coverage or reimbursement rates for 0038U?

References