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CPT 0017U: JAK2 Mutation Sequencing (Exons 12–14)
CPT code 0017U is a Proprietary Laboratory Analyses (PLA) code for JAK2 mutation testing performed by the University of Iowa, Department of Pathology. It specifically denotes sequence analysis of blood or bone marrow specimens to detect JAK2 mutations in exons 12–14. As a PLA code, 0017U identifies a single laboratory’s proprietary assay and is used where precise identification of the performing laboratory and test is required. Nationally, targeted molecular diagnostics like this are important for diagnosis, prognosis, and therapeutic decision-making in hematologic disorders linked to JAK2 alterations.
Key payers examined in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the code’s clinical purpose, typical sites of service, and payer coverage landscape. The publication summarizes benchmark considerations for proprietary molecular tests, discusses common billing modifiers associated with lab services, and outlines the clinical context in which JAK2 sequencing is ordered. Data not available in the input are noted where applicable. The content is written for a national audience and focuses on the code definition, payer scope, and clinical relevance of JAK2 mutation testing under CPT code 0017U.
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Billing Code Overview
CPT code 0017U is a Proprietary Laboratory Analyses (PLA) code that describes a single, manufacturer- or laboratory-specific molecular test. This code represents JAK2 Mutation testing performed by the University of Iowa, Department of Pathology. The assay analyzes gene sequence from blood or bone marrow specimens to report the presence or absence of JAK2 mutations in exons 12–14.
Service type: Molecular diagnostic laboratory test (proprietary JAK2 gene sequencing)
Typical site of service: Clinical laboratory or hospital pathology laboratory; specimens collected from outpatient clinics, inpatient units, or phlebotomy centers.