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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j2270-morphine-injection-up-to-10-mg
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    HCPCS Level II J2270: Morphine Sulfate Injection, Up to 10 mg

    Commercial payers pay $3 on average nationally for this procedure.

    HCPCS Level II code J2270 describes an injection of morphine sulfate, up to 10 mg, intended for analgesia; this code is used for billing a single-dose injectable opioid administered typically as an intravenous or intramuscular medication in settings such as emergency departments, hospital inpatient units, and procedural suites where parenteral pain control is provided.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    National Reimbursement Benchmarks

    National commercial reimbursements for J2270 cluster around BUCA’s average commercial rate of $2.8, with most large payers showing medians near $2.0–$2.2. Blue Cross Blue Shield and Aetna have median rates at $2.00 and $2.00 respectively, while Cigna and UnitedHealth Group show medians of $2.20; Cigna’s mean is a notable outlier at $5.5 driven by a high $59.50 cap. This positions BUCA’s $2.8 mean modestly above several payer medians, reflecting that average commercial payment sits slightly higher than the middle of the major carriers.

    Dispersion measured by the interquartile spread (P75 minus P25) is narrowest for UnitedHealth Group at $0.20 (P75 $2.40 minus P25 $2.20) and relatively tight for Aetna at $1.40 (P75 $2.30 minus P25 $0.90). Blue Cross Blue Shield and BUCA show moderate spreads of $0.80 and $1.10 respectively (BCBS P75 $2.80 minus P25 $2.00; BUCA P75 $3.00 minus P25 $1.90). Cigna exhibits the widest IQR at $2.60 (P75 $4.80 minus P25 $2.20), indicating the greatest middle-range variability among payers.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient presents to the emergency department with acute exacerbation of chronic cancer-related pain and reports severe uncontrolled back pain. The emergency medicine physician performs assessment, documents pain severity and previous opioid use, and orders an immediate parenteral opioid for rapid analgesia. A nurse or clinician prepares and administers J2270 (injection, morphine sulfate, up to 10 mg) intravenously or intramuscularly as indicated. The medication is documented in the medication administration record with dose, route, time, and patient response. Monitoring for respiratory status, level of consciousness, and hemodynamics occurs for the required observation period following administration. If the patient requires a preservative-free preparation, J2274 would be used instead of J2270. Typical sites of service include the emergency department, hospital inpatient unit, observation unit, or outpatient clinics providing urgent analgesia. Documentation supporting medical necessity includes the presenting diagnosis (for example G89.3, M54.5, R52), assessment of pain level, prior analgesic regimen, informed consent when applicable, and objective monitoring after administration.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    261QR0401XComprehensive Outpatient Rehabilitation Facility (CORF)Ambulatory Health Care Facilities · Clinic/Center
    103TF0000XFamily PsychologistA psychologist whose specialty is founded on principles of systems theory with the interpersonal system of the family the focus of assessment, interve…
    364SW0102XWomen's Health Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    156FC0800XContact Lens Technician/TechnologistAn optician or other ancillary support staff person who, where authorized by state law and trained or certified to do so, may fit or dispense contact …
    261QH0100XHealth Service Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C18.9Malignant neoplasm of colon, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.911Malignant neoplasm of unspecified site of right female breast
    F45.41Pain disorder exclusively related to psychological factors
    G89.29Other chronic pain
    G89.3Neoplasm related pain (acute) (chronic)
    I21.4Non-ST elevation (NSTEMI) myocardial infarction
    I63.9Cerebral infarction, unspecified
    M16.11Unilateral primary osteoarthritis, right hip
    M17.11Unilateral primary osteoarthritis, right knee

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    J2274Injection, morphine sulfate, up to 10 mg; preservative freeUse when the administered morphine sulfate is labeled as preservative-free instead of billing J2270.

    Note: No additional CPT drug codes were provided in the input.