Cellulitis with Major Complication or Comorbidity: Inpatient Reimbursement Overview

DRG 602 encompasses inpatient care for cellulitis with a Major Complication or Comorbidity and denotes a higher-acuity soft tissue infection that increases resource utilization. Accurate assignment to this Diagnosis-Related Group matters for inpatient reimbursement because it influences the Medicare payment under the prospective payment system.

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DRG 602 Overview

DRG 602 covers inpatient admissions for cellulitis with a Major Complication or Comorbidity, typically involving severe soft tissue infection requiring systemic therapy and often additional interventions or monitoring. This Diagnosis-Related Group captures higher resource use driven by increased medical complexity, prolonged hospital stay, and potential need for intravenous antibiotics, surgical debridement, or intensive supportive care. It matters for Medicare payment because classification into this group affects hospital reimbursement levels under the inpatient prospective payment system. Accurate clinical documentation and coding determine assignment to this Diagnosis-Related Group and the associated payment weight.

National Payment Rates

Across payers the observed rate range spans from about $370 to $52K, with the widest spread between minimum and maximum seen for Anthem (min $390 to max $52K). Benchmarks for Blue Cross Blue Shield, Aetna, Cigna, and Anthem are shown in the table and chart below. The payer-level means vary notably, indicating substantial variation by commercial payer.

The CMS 2023 data represent national Medicare fee-for-service inpatient payments as reported in the CMS Provider Utilization and Payment Data program. The table below shows average total payment, average submitted covered charges, average Medicare payment, and total discharges for DRG 602. These values reflect aggregated payment and charge amounts across all Medicare FFS discharges in the reporting year.

Average Total Payment	Average Submitted Charges	Average Medicare Payment	Total Discharges
$13K	$57K	$11K	20K

Patient Population

This DRG’s population includes a mix of Medicare-age and working-age patients, with a notable portion captured in Medicare fee-for-service reporting and additional volume covered by commercial payers. The presence of substantial Medicare discharges indicates a meaningful Medicare-age share, while commercial benchmarks show continued representation of working-age enrollees. Overall the payer mix is mixed rather than exclusively Medicare or exclusively commercial.

State Payment Rates

State: Alaska1 / 49

Alaska Benchmarks

Payer rates in Alaska range from $22K to $34K across the three payers, with Anthem and Blue Cross Blue Shield both at $22K and Cigna at $34K. The most notable deviation from national averages is Cigna’s higher mean ($34K), which sits above many national medians. Reference the table and chart below for payer-specific distributions.

Key Insights for Alaska

Highest payer: Cigna (mean $34K); Lowest payers: Anthem and Blue Cross Blue Shield (mean $22K).
Alaska shows a narrow rate band for Anthem and BCBS at $22K, while Cigna is meaningfully higher at $34K, exceeding typical national medians for several payers.

Clinical Trials

Acute antimicrobial regimen trials: randomized controlled trials comparing different intravenous antibiotic regimens, dosing strategies, or adjunctive therapies in hospitalized adults with severe cellulitis complicated by major comorbid conditions (for example diabetes with neuropathy, peripheral vascular disease, or immunosuppression). These studies focus on time to clinical improvement, need for ICU-level care, or prevention of progression to necrotizing infection and are relevant because optimal inpatient antibiotic choice and duration directly affect length of stay, complication rates, and short-term costs for DRG 602 patients. Providers and payers use this evidence to balance clinical efficacy against antimicrobial stewardship and resource utilization.
Comparative effectiveness and care-pathway studies: pragmatic trials or observational comparative studies evaluating different inpatient care pathways such as early surgical consultation vs standard medical management, standardized cellulitis bundles (wound care plus multidisciplinary rounds) versus usual care, or step-down criteria to oral therapy and discharge. These studies typically enroll medically complex inpatients with cellulitis and major comorbid conditions to determine which pathways reduce LOS, readmissions, and avoid escalation to MCC events. Results inform hospital protocols and reimbursement case-mix considerations by identifying interventions that safely shorten hospitalization and lower avoidable high-cost complications for DRG 602.
Post-discharge outcomes and transitional care research: prospective cohort studies and interventional trials testing post-discharge strategies (home health nursing, telehealth wound follow-up, outpatient parenteral antibiotic therapy programs) in patients discharged after hospitalization for cellulitis with major comorbidities. These trials measure 30- to 90-day readmission rates, wound healing, functional recovery, and adverse events related to outpatient management in a population at high risk of relapse or complications. Payers and providers rely on this evidence to design discharge planning and coverage policies that reduce readmissions and downstream costs associated with the DRG while maintaining patient safety.

Related Codes

570-SKIN-DEBRIDEMENT-WITH-MCC

Skin Debridement with Major Complication or Comorbidity: Inpatient Reimbursement Overview

571-SKIN-DEBRIDEMENT-WITH-CC

Skin Debridement with CC: Inpatient Reimbursement Overview

572-SKIN-DEBRIDEMENT-WITHOUT-CC-MCC

Skin Debridement without CC/MCC: Inpatient Reimbursement Overview

573-SKIN-GRAFT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-MCC

Skin Graft for Skin Ulcer or Cellulitis with MCC: Inpatient Reimbursement Overview

574-SKIN-GRAFT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-CC

Skin Graft for Skin Ulcer or Cellulitis with CC: Inpatient Reimbursement Overview

575-SKIN-GRAFT-FOR-SKIN-ULCER-OR-CELLULITIS-WITHOUT-CC-MCC

Skin Graft for Skin Ulcer or Cellulitis without CC/MCC: Inpatient Reimbursement Overview

576-SKIN-GRAFT-EXCEPT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-MCC

Skin Graft Except for Skin Ulcer or Cellulitis with MCC: Inpatient Reimbursement Overview

577-SKIN-GRAFT-EXCEPT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-CC

Skin Graft Except for Skin Ulcer or Cellulitis with CC: Inpatient Reimbursement Overview

578-SKIN-GRAFT-EXCEPT-FOR-SKIN-ULCER-OR-CELLULITIS-WITHOUT-CC-MCC

Skin Graft Except for Skin Ulcer or Cellulitis without CC/MCC: Inpatient Reimbursement Overview

579-OTHER-SKIN-SUBCUTANEOUS-TISSUE-AND-BREAST-PROCEDURES-WITH-MCC

Other Skin, Subcutaneous Tissue and Breast Procedures with MCC: Inpatient Reimbursement Overview

Showing 1–10 of 31

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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National Payment Rates

Mean Rates by Payer — National — DRG 602

Average Total Payment	Average Submitted Charges	Average Medicare Payment	Total Discharges
$13K	$57K	$11K	20K

Patient Population

State Payment Rates

State: Alaska1 / 49

Alaska Benchmarks

Mean Rates by Payer — Alaska — DRG 602

Key Insights for Alaska

Highest payer: Cigna (mean $34K); Lowest payers: Anthem and Blue Cross Blue Shield (mean $22K).
Alaska shows a narrow rate band for Anthem and BCBS at $22K, while Cigna is meaningfully higher at $34K, exceeding typical national medians for several payers.

Clinical Trials

Acute antimicrobial regimen trials: randomized controlled trials comparing different intravenous antibiotic regimens, dosing strategies, or adjunctive therapies in hospitalized adults with severe cellulitis complicated by major comorbid conditions (for example diabetes with neuropathy, peripheral vascular disease, or immunosuppression). These studies focus on time to clinical improvement, need for ICU-level care, or prevention of progression to necrotizing infection and are relevant because optimal inpatient antibiotic choice and duration directly affect length of stay, complication rates, and short-term costs for DRG 602 patients. Providers and payers use this evidence to balance clinical efficacy against antimicrobial stewardship and resource utilization.
Comparative effectiveness and care-pathway studies: pragmatic trials or observational comparative studies evaluating different inpatient care pathways such as early surgical consultation vs standard medical management, standardized cellulitis bundles (wound care plus multidisciplinary rounds) versus usual care, or step-down criteria to oral therapy and discharge. These studies typically enroll medically complex inpatients with cellulitis and major comorbid conditions to determine which pathways reduce LOS, readmissions, and avoid escalation to MCC events. Results inform hospital protocols and reimbursement case-mix considerations by identifying interventions that safely shorten hospitalization and lower avoidable high-cost complications for DRG 602.
Post-discharge outcomes and transitional care research: prospective cohort studies and interventional trials testing post-discharge strategies (home health nursing, telehealth wound follow-up, outpatient parenteral antibiotic therapy programs) in patients discharged after hospitalization for cellulitis with major comorbidities. These trials measure 30- to 90-day readmission rates, wound healing, functional recovery, and adverse events related to outpatient management in a population at high risk of relapse or complications. Payers and providers rely on this evidence to design discharge planning and coverage policies that reduce readmissions and downstream costs associated with the DRG while maintaining patient safety.

Related Codes

570-SKIN-DEBRIDEMENT-WITH-MCC

Skin Debridement with Major Complication or Comorbidity: Inpatient Reimbursement Overview

571-SKIN-DEBRIDEMENT-WITH-CC

Skin Debridement with CC: Inpatient Reimbursement Overview

572-SKIN-DEBRIDEMENT-WITHOUT-CC-MCC

Skin Debridement without CC/MCC: Inpatient Reimbursement Overview

573-SKIN-GRAFT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-MCC

Skin Graft for Skin Ulcer or Cellulitis with MCC: Inpatient Reimbursement Overview

574-SKIN-GRAFT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-CC

Skin Graft for Skin Ulcer or Cellulitis with CC: Inpatient Reimbursement Overview

575-SKIN-GRAFT-FOR-SKIN-ULCER-OR-CELLULITIS-WITHOUT-CC-MCC

Skin Graft for Skin Ulcer or Cellulitis without CC/MCC: Inpatient Reimbursement Overview

576-SKIN-GRAFT-EXCEPT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-MCC

Skin Graft Except for Skin Ulcer or Cellulitis with MCC: Inpatient Reimbursement Overview

577-SKIN-GRAFT-EXCEPT-FOR-SKIN-ULCER-OR-CELLULITIS-WITH-CC

Skin Graft Except for Skin Ulcer or Cellulitis with CC: Inpatient Reimbursement Overview

578-SKIN-GRAFT-EXCEPT-FOR-SKIN-ULCER-OR-CELLULITIS-WITHOUT-CC-MCC

Skin Graft Except for Skin Ulcer or Cellulitis without CC/MCC: Inpatient Reimbursement Overview

579-OTHER-SKIN-SUBCUTANEOUS-TISSUE-AND-BREAST-PROCEDURES-WITH-MCC

Other Skin, Subcutaneous Tissue and Breast Procedures with MCC: Inpatient Reimbursement Overview

Showing 1–10 of 31

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.