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    v1.0.28
    OpenPayerBilling CodesDiseases and Disorders of the Digestive SystemDRG 384-uncomplicated-peptic-ulcer-without-mcc
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    Uncomplicated Peptic Ulcer without MCC: Inpatient Reimbursement Overview

    DRG 384 pertains to inpatient stays for uncomplicated peptic ulcer disease without Major Complication or Comorbidity, encompassing straightforward medical or endoscopic management. Proper assignment matters for inpatient reimbursement because it reflects lower expected resource use and influences Medicare payment classification.

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    DRG 384 Overview

    DRG 384 covers hospital admissions for uncomplicated peptic ulcer disease without Major Complication or Comorbidity, typically managed with medical therapy or limited endoscopic intervention. This Diagnosis-Related Group groups patients with relatively low resource use compared with ulcer cases that have complications, which affects payment assignment and hospital case-mix. For Medicare payment, accurate coding of ulcer diagnosis and absence of Major Complication or Comorbidity is essential to assign this Diagnosis-Related Group and determine inpatient reimbursement. Understanding this clinical scope helps clarify expected resource intensity and billing classification.

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    Clinical Trials

    • Acute management randomized trials comparing strategies for initial hemostasis in hospitalized patients with bleeding peptic ulcers: these studies enroll adults admitted with active upper GI bleeding or recent endoscopic evidence of ulcer bleeding and randomize to different endoscopic techniques, adjunctive pharmacologic protocols, or timing of second-look endoscopy. The objective is to determine which immediate interventions reduce rebleeding, transfusion needs, length of stay, and inpatient resource utilization. Results inform clinicians on best-practice acute care pathways and help payers anticipate procedure use and short-term cost drivers for this DRG.
    • Comparative effectiveness studies of maintenance medical regimens to prevent recurrent ulcer complications in patients without major comorbidities: prospective cohort or pragmatic randomized trials evaluate different acid suppression strategies, Helicobacter pylori testing-and-eradication pathways, and NSAID-sparing protocols among patients hospitalized for uncomplicated peptic ulcer disease. These studies focus on mid-term outcomes such as recurrence rates, readmissions, medication adherence, and adverse effects, addressing the transition from inpatient stabilization to outpatient prevention. Findings are relevant for discharge planning, formulary decisions, and reducing readmission-associated costs for the uncomplicated peptic ulcer population.
    • Post-discharge outcomes and health services research examining factors associated with readmission, functional recovery, and outpatient follow-up adherence in patients treated for uncomplicated peptic ulcers: observational registry studies or claims-based analyses identify predictors (for example, socioeconomic status, follow-up access, H. pylori eradication status) of 30- and 90-day readmissions and downstream complications. The aim is to quantify real-world utilization patterns, long-term morbidity, and cost implications of different discharge care bundles or care coordination interventions. This research guides quality improvement initiatives, care transition programs, and payer strategies to reduce avoidable post-discharge utilization in this DRG.

    Related Codes

    326-STOMACH-ESOPHAGEAL-AND-DUODENAL-PROCEDURES-WITH-MCC

    Stomach, Esophageal and Duodenal Procedures with MCC: Inpatient Reimbursement Overview

    327-STOMACH-ESOPHAGEAL-AND-DUODENAL-PROCEDURES-WITH-CC

    Stomach, Esophageal and Duodenal Procedures with CC: Inpatient Reimbursement Overview

    328-STOMACH-ESOPHAGEAL-AND-DUODENAL-PROCEDURES-WITHOUT-CC-MCC

    Stomach, Esophageal and Duodenal Procedures without CC/MCC: Inpatient Reimbursement Overview

    329-MAJOR-SMALL-AND-LARGE-BOWEL-PROCEDURES-WITH-MCC

    Major Small and Large Bowel Procedures with MCC: Inpatient Reimbursement Overview

    330-MAJOR-SMALL-AND-LARGE-BOWEL-PROCEDURES-WITH-CC

    Major Small and Large Bowel Procedures with CC: Inpatient Reimbursement Overview

    331-MAJOR-SMALL-AND-LARGE-BOWEL-PROCEDURES-WITHOUT-CC-MCC

    Major Small and Large Bowel Procedures without CC/MCC: Inpatient Reimbursement Overview

    332-RECTAL-RESECTION-WITH-MCC

    Rectal Resection with MCC: Inpatient Reimbursement Overview

    333-RECTAL-RESECTION-WITH-CC

    Rectal Resection with CC: Inpatient Reimbursement Overview

    334-RECTAL-RESECTION-WITHOUT-CC-MCC

    Rectal Resection without CC/MCC: Inpatient Reimbursement Overview

    335-PERITONEAL-ADHESIOLYSIS-WITH-MCC

    Peritoneal Adhesiolysis with MCC: Inpatient Reimbursement Overview

    Showing 1–10 of 57

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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