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    OpenPayerBilling CodesDiseases and Disorders of the Ear, Nose, Mouth and ThroatDRG 141-major-head-and-neck-procedures-with-cc
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    Major Head and Neck Procedures with CC: Inpatient Reimbursement Overview

    DRG 141 includes major head and neck surgical procedures accompanied by at least one Complication or Comorbidity, covering extensive resections and reconstructions of the oral cavity, pharynx, larynx, and related structures. Assignment to this Diagnosis-Related Group affects inpatient reimbursement because the Complication or Comorbidity designation reflects higher expected resource use under Centers for Medicare & Medicaid Services payment rules.

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    DRG 141 Overview

    DRG 141 covers major head and neck surgical procedures when a patient has at least one Complication or Comorbidity. This Diagnosis-Related Group encompasses extensive resections, reconstructions, and other complex operative interventions involving the oral cavity, pharynx, larynx, salivary glands, and related structures. It matters for Medicare payment because the presence of Complication or Comorbidity increases resource use and thus affects inpatient reimbursement under the Centers for Medicare & Medicaid Services payment methodology. Accurate clinical coding of procedures and comorbid conditions determines assignment to this Diagnosis-Related Group and influences payment levels.

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    Clinical Trials

    • Trials of perioperative airways and critical care management: randomized or observational studies focusing on strategies to prevent or manage airway compromise, bleeding, and immediate postoperative respiratory complications in adults undergoing major head and neck resections with comorbid conditions (eg, COPD, obstructive sleep apnea, anticoagulation). These studies enroll patients in the immediate perioperative period and compare protocols such as elective tracheostomy timing, enhanced monitoring pathways, or blood-conservation techniques to reduce ICU transfers and emergency reintubation. Results are highly relevant to surgeons, anesthesiologists, and hospital administrators because perioperative complications drive length of stay, resource use, and short-term readmissions billed under this DRG.
    • Comparative effectiveness studies of reconstructive approaches and functional outcomes: prospective cohort studies or pragmatic trials comparing flap types (eg, free microvascular flap versus regional pedicled flap) or surgical techniques in patients undergoing major resections for advanced head and neck cancers who also have complicating comorbidities. These studies evaluate wound healing, speech and swallowing function, complication rates, and need for revision surgery over 30–90 days and up to one year, informing which approaches offer the best balance of durability and lower complication burden for medically complex inpatients. Payers and providers use this evidence to anticipate inpatient resource intensity, postoperative rehabilitation needs, and downstream costs tied to complications or additional procedures within the DRG payment period.
    • Post-discharge outcomes and care coordination research: observational studies and interventions testing enhanced discharge planning, early outpatient follow-up, home nursing, and nutrition/swallowing rehabilitation for survivors of major head and neck procedures with complications. These studies target patients with CCs (eg, malnutrition, wound infection risk, or dependence on enteral feeding) and measure 30-day readmissions, emergency visits, functional recovery, and patient-reported outcomes to identify approaches that reduce preventable returns to acute care. Findings help hospitals and payers design transitional care programs to lower readmission rates and total cost of care associated with this high-acuity DRG.

    Related Codes

    135-SINUS-AND-MASTOID-PROCEDURES-WITH-CC-MCC

    Sinus and Mastoid Procedures with CC/MCC: Inpatient Reimbursement Overview

    136-SINUS-AND-MASTOID-PROCEDURES-WITHOUT-CC-MCC

    Sinus and Mastoid Procedures without CC/MCC: Inpatient Reimbursement Overview

    137-MOUTH-PROCEDURES-WITH-CC-MCC

    Mouth Procedures with CC/MCC: Inpatient Reimbursement Overview

    138-MOUTH-PROCEDURES-WITHOUT-CC-MCC

    Mouth Procedures without CC/MCC: Inpatient Reimbursement Overview

    139-SALIVARY-GLAND-PROCEDURES

    Salivary Gland Procedures: Inpatient Reimbursement Overview

    140-MAJOR-HEAD-AND-NECK-PROCEDURES-WITH-MCC

    Major Head and Neck Procedures with MCC: Inpatient Reimbursement Overview

    142-MAJOR-HEAD-AND-NECK-PROCEDURES-WITHOUT-CC-MCC

    Major Head and Neck Procedures without CC/MCC: Inpatient Reimbursement Overview

    143-OTHER-EAR-NOSE-MOUTH-AND-THROAT-O-R-PROCEDURES-WITH-MCC

    Other Ear, Nose, Mouth and Throat O.R. Procedures with MCC: Inpatient Reimbursement Overview

    144-OTHER-EAR-NOSE-MOUTH-AND-THROAT-O-R-PROCEDURES-WITH-CC

    Other Ear, Nose, Mouth and Throat O.R. Procedures with CC: Inpatient Reimbursement Overview

    145-OTHER-EAR-NOSE-MOUTH-AND-THROAT-O-R-PROCEDURES-WITHOUT-CC-MCC

    Other Ear, Nose, Mouth and Throat O.R. Procedures without CC/MCC: Inpatient Reimbursement Overview

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    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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